Antiviral compounds of fosfodiamida beta amino acid ester

摘要

The present Invention relates to a compound of formula I, in which R1 and R2 are each independently selected from h, c1-c4 alkyl, phenyl - CH2 -,Among others; R3 is C1 - C10 alkyl unsubstituted, - CH2 - unsubstituted aryl phenyl, not replaced, among others, ra is a rest of L - amino acid ester of formula I,A rest of D - amino acid ester of formula II, among others; R4 is c1-c4 alkyl, aryl - CH2 - phenol; R9 is C1 - C10 alkyl, aryl phenyl - CH2 -, not replaced, among others.Compounds are Favorites: N - [(S) - {[(1R) - 2 - (6 - amino - 9h purin - 9 - yl) methyl] - 1 - metiletoxi} {[(2S) - 2 - methyl - 3 - (1 - metiletoxi) - 3-oxopropyl] amino} fosforil l-alaninate] - 1 - metiletilico; n - [(R) - {[(1R) - 2 - (6 - amino - 9H - slurry - 9 - yl) methyl] - 1 - metiletoxi} {[(2S) - 2 - methyl - 3 - (1 - metiletoxi) - 3-oxopropyl] amino} - 1] fosforil l-alaninate - metiletilico, among others.The present Invention also relates to a Pharmaceutical composition comprising an effective amount of one or more HIV antiviral agent such as abacavir, efavirenz,Among others, and a pharmaceutically acceptable vehicle.It is useful for the inhibition of HIV reverse transcriptase, both for its Prevention, Treatment and prophylaxis and / or delay the onset or progression of AIDS and / or ARC.