Modulation of the expression of Signal Transducer and Activator of Transcription 3 (STAT3)

摘要

Refers to a compound comprising an oligonucleotide modified Nucleosides is 12 to 30 United has a nucleobase Sequence that includes a portion of at least 12 nuclEobases complementary adjacent a portion of equal length of nucleobases 3008 at 3033 of SEQ ID no: 1, where the sequence of nucleobases is complementary to the SEQ ID no: 1.It also relates to a method to decrease the expression of STAT3 mRNA and Protein. These compounds are useful for the treatment of hyperproliferative diseases.