Method of preparation of (+) - 1,4-dihydro-7 - (3S, 4S) -3-methoxy-4- (methylamino) -1-pyrrolidinyl -4-oxo-1- (2-thiazolyl) -1,8-naphthyridine-3-carboxylic

摘要

A process comprising: i) the epoxy opening compound 3 ** Formula *** with methylamine to obtain Compound 4 ** Formula ** and ii) resolving Compound 4 with a chiral acid selected from L - (- ) -Malic and L - (-) - pyroglutamic acid to provide Compound 5A or 5B ** Formula **