Motilin-like peptide compound that has a transmucosal absorption susceptibility imparted thereto

摘要

A compound comprising the sequence represented by the following general formula 1: X1 Val X2 Ile Phe Thr Tyr Gly X3 Leu Gln Arg X4 Gln Glu Lys Glu Arg X5 Lys Pro Gln (formula 1) [in which all linkages between amino acids, except for the X1-Val bond, they are amide bonds; the X1-Val bond is an amide bond or a bond represented by the following formula 2 ** Formula ** X1 is phenylalanine, ß-homophenylglycine or acetylnaphthylalanine; X2 is proline or sarcosine; X3 is glutamic acid or aspartic acid; X4 is methionine or leucine; X5 is asparagine or proline] or a pharmaceutically acceptable salt thereof, in which the compound has a motilin-like activity that stimulates gastrointestinal motility and shows a higher absorption efficiency after transmucosal administration compared to native motilin