Antisulfate and anti-sulfated proteoglycan antibodies and their use

摘要

The present invention is related to the field of biotechnology and particularly with new products to be used in human health. The present invention provides new monoclonal antibodies that specifically recognize and with high affinity sulfates and sulfated proteoglycans. The sulfated anti-sulfatide and anti-proteoglycan antibodies described herein provide important diagnostic and therapeutic agents to act on pathological processes associated with the appearance of atherosclerotic plaques. Accordingly, the invention provides pharmaceutical compositions comprising the monoclonal antibodies of the invention or fragments derived from these antibodies for therapeutic and diagnostic use associated with cardiovascular diseases. Additionally, the present invention relates to the fragments of the monoclonal antibodies that recognize sulfated sulfates and proteoglycans, so that said fragments can be used in the therapy or diagnosis of this pathology.