Inhibitors of the Notch signaling pathway and their use in the treatment of cancers

摘要

A compound for use in the treatment and / or prevention of a Notch-dependent cancer, wherein said compound having properties of inhibition of the Notch signaling pathway is selected from the group consisting of: 6- (4- (terc -butylphenoxy) pyridin-3-amine (I3) of formula I ** (See formula) ** 4- (4-cyclohexylphenoxy) aniline of formula III to ** (See formula) ** 6- (4 - ((3r , 5r, 7r) -adamantan-1-yl) phenoxy) pyridin-3-amine of formula IVa ** (See formula) ** 6- (3- (tert-butyl) phenoxy) pyridin-3-amine of formula IIe ** (See formula) ** 4- (4- (tert-butyl) phenoxy) -3-fluoroaniline of formula IIf ** (See formula) ** 6- (4- (tert-pentyl) phenoxy) pyridin-3 -amine of formula IIg ** (See formula) ** 6- (4-butylphenoxy) pyridin-3-amine of formula IIh ** (See formula) ** 3-Fluoro-4- (4-tert-pentyl) phenoxy ) aniline of formula II i ** (See formula) ** 4- (4-Cyclohexylphenoxy) -3-fluoroaniline of formula III b ** (See formula) ** 4- (4 - ((3r, 5r, 7r) -adamantan-1-yl) phenoxy) -3-fluoroaniline of formula IVb ** (See pho formula) ** 6- (4-Cyclohexylphenoxy) pyridine-3-amine of formula IIIc ** (See formula) ** or one of its salts, solvates, tautomers or stereoisomers thereof.