Method for preparing 1- (4- (4- (3,4-dichloro-2-fluorophenylamino) -7-methoxyquinazolin-6-yloxy) piperidin-1-yl) prop-2-en-1-one

摘要

A method for preparing the compound of formula (I), which comprises the step of allowing the compound of formula (II) to react with the compound of formula (III) in an inert polar aprotic solvent in the presence of a base: ** Formula ** wherein X is tosyloxy (OT), mesyloxy (OMs), trifluoromethanesulfonate, fluorosulfonate or halogen; and Y is ethenyl or halogenoethyl.