Water soluble prodrugs of acetaminophen and related compounds with positively charged a rate of penetration of the skin very quickly

摘要

A compound has a General formula Structure 1 or a composition comprising at least one Compound has a General formula Structure 1, as the active ingredientFor use in the treatment of a condition in a human or animal by transdermal Administration * * * * in the formula: R1 is selected from the group consisting of H,Waste alkyl with 1 to 12 carbon ATOMS, residues alquiloxi having 1 to 12 carbon Atoms.Alquenilo residues that have up to 12 carbon Atoms and residues alquinilo with up to 12 carbon Atoms; R2 is selected from the group consisting of H,Waste alkyl with 1 to 12 carbon ATOMS, residues alquiloxi having 1 to 12 carbon Atoms.Alquenilo residues that have up to 12 carbon Atoms and residues alquinilo with up to 12 carbon Atoms; R3 is h; X represents o or 2 - or OCO - C6H4 -; - represents a negative ion; n = 0, 1,2, 3, 4, 5, 6, 7, 8, 9 or 10; and the condition selected from the group consisting of Pain, cancer, dysmenorrhea, Fever, vomiting induced by Radiation, diabetic neuropathy, hemophilic arthropathy.Bone loss, psoriasis, acne, Skin Disorders and Sunburn.