Immunotherapy using alo-NKT cells, cells for immunotherapy in which the alpha chain of the T cell receptor gene (TCR) has been redistributed to uniform V alpha-J alpha, and NKT cell bank derived from said cells

摘要

NKT cells for use in the prevention and / or treatment of cancer, where NKT cells have been obtained by differentiating in vitro cells that have the α chain region of the T cell antigen receptor gene redistributed to uniform Vα-Jα in a specific manner of the NKT cell receptor, where the NKT cells are administered to an allogeneic subject having at least one genotype of a different locus from that of the NKT cells at the MHC gene loci, and where the cell receptor NKT is a T cell receptor that specifically recognizes α-galactosylceramide presented on CD1d.