UNACYLATED GHRELIN AND ANALOGS AS THERAPEUTIC AGENTS FOR VASCULAR REMODELING IN DIABETIC PATIENTS AND TREATMENT OF CARDIOVASCULAR DISEASE

摘要

The present invention relates to a method for treating a cardiovasculardisease, for increasing the number of circulatingangiogenic cells (CAC) and/or improving the function of CAC and a method forimproving vascular remodeling and/or neovascularisation.The method comprises administering to the subject a therapeutically effectiveamount of unacylated ghrelin or apolypeptide comprising the amino acid sequence set forth in SEQ ID NO: 1 or afragment or analog thereof having the biologicalactivity of SEQ ID NO: 1; and to pharmaceutical compositions comprisingunacylated ghrelin or a polypeptide comprising theamino acid sequence set forth in SEQ ID NO: 1 or a fragment or analog thereofhaving the biological activity of SEQ ID NO: 1.