RECOMBINANT HUMAN G-CSF DIMER AND USE THEREOF FOR THE TREATMENT OF NEUROLOGICAL DISEASES

摘要

Provided is a recombinant human G-CSF (rhG-CSF) dimer having prolonged serumhalf-life and increased biologicalactivity of G-CSF, wherein the dimer is produced by two G-CSF-Fc complexesthrough the pairing of two Fc fragments viadisulfide bonds, and the G-CSF-Fc complex comprises a G-CSF monomer, an Fcfragment of human IgG2, and a peptide connectingthe G-CSF monomer and the Fc fragment. The rhG-CSF can be used for thetreatment of neurological diseases.