CONDITIONALLY ACTIVE PH-DEPENDENT CETUXIMAB VARIANT ANTI-EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODIES AND METHOD OF USE THEREOF

摘要

Provided herein are modified anti-EGFR antibodies and nucleic acid moleculesencoding modified anti-EGFR antibodies. In particular, provided herein arecetuximab variantanti-EGFR antibodies which are conditionally active in a tumor environmentand/or bindEGFR at a lower pH than unmodified cetuximab. Also provided are methods oftreatment anduses using modified anti-EGFR antibodies, such as for treatment of a conditionresponsive toan anti-EGFR antibody (e.g. cancer).