The present disclosure generally relates a fiducial marker deployment system configured for controlled deployment of at least one of a plurality of preloaded specially- configured fiducials in a controlled serial manner to a desired target site. The deployment system generally includes a deployment device configured to deploy at least one of a plurality of preloaded fiducials to a target site within a patient via a rotational deployment mechanism. Each fiducial generally includes a pellet-like body having a groove helically formed along an outer surface thereof and the deployment device includes a deployment catheter having an internally threaded lumen configured to engage the helical groove of each fiducial so as to allow rotational loading and deployment of each fiducial.
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