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HYDROGEL SYSTEMS FOR SKELETAL INTERFACIAL TISSUE REGENERATION APPLIED TO EPIPHYSEAL GROWTH PLATE REPAIR
HYDROGEL SYSTEMS FOR SKELETAL INTERFACIAL TISSUE REGENERATION APPLIED TO EPIPHYSEAL GROWTH PLATE REPAIR
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机译:骨界面组织再生的水凝胶系统在表皮生长板修复中的应用
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摘要
Described herein are biomaterials, systems, and methods for guiding regeneration of an epiphyseal growth plate or similar interfacial tissue structures. In one aspect, the disclosed technology can include a biologic material that can comprise one or more of a hydrogel carrier for growth factors and MSCs, chondrogenic and immunomodulatory cytokines, microparticles for prolonged and spatially controlled growth factor delivery; and/or porous scaffold providing mechanical support. The implanted material can be applied via various different modalities depending on the nature of the physeal injury. One modality is an injectable hydrogel and another modality is an implantable hydrogel infused scaffold.
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