EXTRACELLULAR VESICLES, METHODS OF MAKING THEM, AND METHODS OF REDUCING LIVER UPTAKE OF EXTRACELLULAR VESICLES

摘要

An isolated or purified extracellular vesicle comprising a membrane comprising a phospholipid bilayer and a heterodimeric complex of interleukin-15 and interleukin-15 receptor alpha is disclosed. Also provided are methods of preparing isolated or purified extracellular vesicles comprising a therapeutic protein, methods of reducing liver uptake of extracellular vesicles administered to a mammal, and methods of treating or preventing cancer in a mammal.