首页> 外国专利> METHOD FOR PREDICTING OBESITY RELATED DISEASE USING IMAGES OF THE SUBCUTANEOUS ADIPOSE TISSUE OR THE EPIDIDYMAL ADIPOSE TISSUE

METHOD FOR PREDICTING OBESITY RELATED DISEASE USING IMAGES OF THE SUBCUTANEOUS ADIPOSE TISSUE OR THE EPIDIDYMAL ADIPOSE TISSUE

机译:利用皮脂组织或附睾组织的图像预测肥胖相关疾病的方法

摘要

The present invention relates to obesity related diseases, such as cancer of non- alcoholic fatty liver disease (NAFLD). Tissue perfusion is currently investigated by using dynamic contrast-enhanced magnetic resonance imaging which is an invasive technique and does not provide enough accuracy. As a result, the inventors worked on post- processing images of subcutaneous adipose tissue or the epididymal adipose tissue taken with a magnetic resonance imaging technique and a multifrequency magnetic resonance elastography technique to obtain parameters such as loss modulus and storage modulus which are more accurate for a diagnosing purpose. This post-processing method may be applied for a method for predicting that a subject is at risk of suffering from said disease, identifying a therapeutic target or a biomarker and screening compounds useful as medicine.
机译:本发明涉及与肥胖有关的疾病,例如非酒精性脂肪肝疾病(NAFLD)的癌症。当前,通过使用动态造影增强磁共振成像来研究组织灌注,动态造影增强磁共振成像是一种侵入性技术,无法提供足够的准确性。结果,发明人对利用磁共振成像技术和多频磁共振弹性成像技术拍摄的皮下脂肪组织或附睾脂肪组织的后处理图像进行了后处理图像,从而获得了诸如损耗模量和储能模量的参数,这些参数对于诊断目的。该后处理方法可以用于预测受试者处于患所述疾病的风险,鉴定治疗靶标或生物标记并筛选可用作药物的化合物的方法。

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