USE OF CELL FREE DNA AS A MEASURE OF ORGAN HEALTH FOLLOWING TRANSPLANTATION

摘要

The present disclosure relates to the use of donor-specific cell-free DNAfor detecting organ transplant rejection, organ dysfunction or organ failure as well as organ transplant health. Donor-specific cell-free DNA is quantified using a probe-free quantitative PCR comprising the use of allele specific forward or reverse primers which fully hybridise to at least one donor specific deletion/insertion (DIP) allelic sequence.