PREPARATION OF MEDICINAL SILICA MICROSPHERES AND USE THEREOF IN PHARMACY FIELD

摘要

Silica microspheres are obtained by melting or grinding high purity silica as a raw material and are purified to reach the requirements of being a pharmaceutical excipient. The silica microspheres have good roundness and mechanical strength, the particle size being in a range of 40 to 250 μm, and the bulk density being in a range of 1.2 to 1.6 g/cm³. By applying the silica microspheres in the pharmacy field as blank pill cores for a wuster coating, a coating process for a granular preparation with a size smaller than 150 μm can be realized while taste masking, sustained release and controlled release can be achieved. On the basis of a proper particle size distribution, the higher bulk density, mechanical strength and good roundness, the yield of a coating on a particle with a size smaller than 150 μm can be greatly increased, and the yield of the coating is 90% or above.