PERFUSION LOOP ASSEMBLY FOR AN EX-VIVO LIVER PERFUSION AND A LIVER CHAMBER ASSEMBLY

摘要

The present disclosure relates to a perfusion loop assembly for ex vivo liver perfusion comprising at least one pump (101) for providing perfusion fluid to the hepatic artery (111) and the portal vein (121) through a first branch line (110) and a second branch line (120), repectively; a liver chamber assembly (130); a liver outlet line (140) configured to be attached to the vena cava (142) and at least one reservoir (150). The second branch line comprises at least one valve (122). The perfusion loop assembly further comprises a gas exchanger (112). Sensors (114, 124, 143, 113, 123, 141) and a control system (30) may also be provided. The disclosure also relates to a liver chamber assembly that comprises a liver support structure and means for mechanically manipulating, in particular compressing, at least a part of the perfused liver ex vivo.