A DRUG DELIVERY SYSTEM FOR THE PREVENTION OF CEREBRAL VASOSPASM

摘要

#$%^&*AU2016201681B220171123.pdf#####ABSTRACT A flowable, sustained release pharmaceutical composition for treating cerebral vasospasm in a human subject, the pharmaceutical composition comprising: a) a therapeutic amount of a therapeutic agent selected from the group consisting of a calcium channel antagonist, an endothelin (ET) receptor antagonist, a transient receptor potential (TRP) channel antagonist, and a combination thereof; and b) a pharmaceutically acceptable carrier, wherein the carrier comprises a plurality of particles, and wherein the therapeutic agent may be dispersed throughout each particle, adsorbed into the particles or contained by the particles in a core surrounded by a coating, wherein the pharmaceutical composition is formulated for local delivery so that it is capable of flowing around a cerebral artery at risk of vasospasm without entering the systemic circulation in an amount to cause unwanted side effects, and wherein the therapeutic amount is capable of producing a localized pharmacologic effect, wherein the therapeutic amount is effective to treat the cerebral vasospasm.