The invention provides atropine sulfate (AS) rapidly-disintegrating sublingual tablets (RDSTs) of improved formulation in a sublingual dosage form and methods for therapeutic use of the AS RDSTs for treatment of organophosphate (OP) exposure and acute toxicity. The AS RDSTs provide an alternative easy-to-use dosage form for the management of organophosphate toxicity. Additionally, the invention provides methods for improved formulation and quality evaluation of the atropine sulfate rapidly-disintegrating sublingual tablets.
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机译：本发明提供了舌下剂型中改良制剂的硫酸阿托品（AS）快速崩解舌下片剂（RDST），以及用于治疗有机磷酸酯（OP）暴露和急性毒性的AS RDST的治疗用途的方法。 AS RDST为管理有机磷酸酯毒性提供了一种易于使用的替代剂型。另外，本发明提供了用于改善阿托品硫酸盐快速崩解舌下片剂的制剂和质量评估的方法。
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