#$%^&*AU2018100819A420180802.pdf#####6 Pharmaceutical hormone intermediates 11-ketone-16a, 17a-epoxy progesterone synthesis method Abstract 5 The present invention discloses pharmaceutical hormone intermediates 11-ketone-16a, 17a-epoxy progesterone synthesis method, comprises the following steps: 2-bromine-ila-hydroxy-14-amino-16a, 17a-epoxy progesterone, sodium sulfate solution were added to the reaction vessel, controlled the stirring speed, 10 controlled the temperature of the solution, reacted; added furan carboxylic acid ethyl ester solution and antimony trichloride powder, raised the temperature of the solution, reacted, added potassium chloride solution, lay up, got crystal, filter, washed with the sodium nitrate solution for several times, washed with the 2,6-dimethyl pyridine solution for several times, washed with the difluorodichloromethane solution for 15 several times, re-crystallized in the diethylene glycol ether solution, dehydrated with dehydration, got the finished product 11 -ketone- 1 6a, 17a-epoxy progesterone.
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