An analysis method of the applicants of precision medicine in salt sensitive hypertension

摘要

#$%^&*AU2018101291A420181011.pdf#####Abstract This invention studies the therapeutic effects Diuretics, Calcium Antagonists and ACEI these three major types of medicines associated the treatment of salt sensitive hypertension can apply on various population with different genotype. Select 10 drugs from the three major types of medicine of salt sensitive hypertension with relatively high market share, screen 54 sites related to the therapeutic effects of drugs through panel designing, whole exome sequencing, identifying and annotating variable sites by exploiting software BWA, Picard-tools, GATK and Annovar, excavate relevant information of targeting genetic locus and corresponding drugs. The process provides a relatively persuasive combination of variable sites exist in aforementioned drugs, with its associated drugs information, level of documents, specific description of relevant genes and details in documents, crowds' frequency, target and its metabolism and transporter. This method exhibits new angles and accomplishments correlated to various other researches of salt sensitive hypertension in the field of genome study, meanwhile assists doctors in providing optimal clinical drug therapy according to reference for differences in individuals' genotype. 1