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IMPROVED METHODS OF TREATING LUNG CANCER USING MULTIPLEX PROTEOMIC ANALYSIS
IMPROVED METHODS OF TREATING LUNG CANCER USING MULTIPLEX PROTEOMIC ANALYSIS
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机译:多重蛋白质组学方法改良的肺癌治疗方法
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摘要
The present invention provides methods for treating cancer patients comprising assaying tumor tissue from patients and identifying those patients most likely to respond to treatment with a platinum-based agent, such as cisplatin, in combination with pemetrexed. Methods are provided for identifying those lung cancer patients most likely to respond to treatment with the combination of cisplatin + pemetrexed chemotherapy agents ("CDDP+PEM") by determining expression patterns of a set of 38 specific proteins directly in tumor cells derived from patient tumor tissue using SRM mass spectrometry. The method further comprising determining if the patient will respond to treatment with combination therapy, and when proteomic analysis of patient tissue indicates that the patient will respond to treatment with combination therapy, the patient is administered a regimen that includes the pemetrexed/p!atinum agent combination.
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