INJECTABLE HYDROGELS THAT PROMOTE MINERALIZATION AND AFFORD SUSTAINED RELEASE OF BIOACTIVE IONS

摘要

Provided is a hybrid hydrogel stabilized by multivalent crosslinking domains. The hydrogel combines inorganic nanoparticles along with an organic polymer network. The resulting material has reinforced mechanical properties and significant mineralization, and affords sustained long-term release of ions. Furthermore, ions released from the hydrogel can enhance cell spreading and promote the osteogenic differentiation of implanted cells. These promising results indicate that the provided compositions and methods are particularly appealing for bone regenerative applications.