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FLUORESCENCE-BASED REPORTERS FOR MUTAGENESIS DETECTION IN E. COLI
FLUORESCENCE-BASED REPORTERS FOR MUTAGENESIS DETECTION IN E. COLI
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机译:基于荧光的报告子,用于 E中的致突变检测。花旗银行 I>
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摘要
Direct detection of mutagenesis in prokaryotes by reversion of an inactivating mutation (reversion mutation assay), producing a quantitative signal for in vivo mutagenesis, may greatly reduce the amount of test chemicals and labor involved in these assays. Further, transcriptional coupling of β-lactamase reversion and GFP, translational fusion between β-lactamase and GFP with stop codon in GFP, and a novel dual reporter to monitor continuous mutagenesis may be used in methods described herein.
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