SMALL-MOLECULE RNA OF RNA-TARGETING HELICASE DHX33 AND APPLICATIONS THEREOF

摘要

A small-molecule RNA of RNA-targeting helicase DHX33 or a complementary sequence thereof, a nucleic acid comprising a nucleic acid sequence for coding the small-molecule RNA or a complementary sequence thereof, and a slow viral plasmid and a slow virus containing the small- molecule RNA or the nucleic acid sequence thereof. The small-molecule RNA contains a sequence TTGGGAAGCTGGTT GGCTATA, can knock down the content of a DHX33 protein to enable the content to reach a basic normal level, and reduces the carcinogenicity and cancer maintenance features of C-MYC, thereby achieving the objective for cancer treatment.