首页> 外国专利> MESENCHYMAL STEM CELL LINE USEFUL FOR DEVELOPING FIBROSIS TREATMENT AGENT

MESENCHYMAL STEM CELL LINE USEFUL FOR DEVELOPING FIBROSIS TREATMENT AGENT

机译:骨髓间充质干细胞系可用于发展纤维化治疗剂

摘要

The present invention relates to a mesenchymal stem cell line useful for developing a fibrosis treatment agent and, particularly, to hepatic stellate cell-derived mesenchymal stem cell line ONGHEPA1(KCTC 13086BP) which is characterized by inducing fibrosis by way of TGF-β or PDGF treatment, and to a method for screening a fibrosis treatment agent by using the mesenchymal stem cell line. The mesenchymal stem cell line according to the presentinvention can be very useful not only as a fibrosis model of a cell or tissue, but also as a cell for developing a new fibrosis treatment agent. Further, the screening method according to the present invention can accurately and efficiently screen a fibrosis treatment agent from a variety of candidate substances.
机译:本发明涉及一种可用于开发纤维化治疗剂的间充质干细胞系,尤其涉及肝星状细胞来源的间充质干细胞系ONGHEPA1(KCTC 13086BP),其特征在于通过TGF-β或PDGF诱导纤维化。治疗,以及通过使用间充质干细胞系筛选纤维化治疗剂的方法。根据本发明的间充质干细胞系不仅可以非常有用地用作细胞或组织的纤维化模型,而且还可以用作开发新的纤维化治疗剂的细胞。此外,根据本发明的筛选方法可以从多种候选物质中准确有效地筛选纤维化治疗剂。

著录项

  • 公开/公告号WO2018147504A1

    专利类型

  • 公开/公告日2018-08-16

    原文格式PDF

  • 申请/专利权人 OSTEONEUROGEN INC.;

    申请/专利号WO2017KR03293

  • 发明设计人 YOUN BYUNG SOO;KIM HAN SOO;KIM JUN HWAN;

    申请日2017-03-28

  • 分类号C12N5/0775;G01N33/50;C12Q1/68;

  • 国家 WO

  • 入库时间 2022-08-21 12:43:04

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