NON-ANTICOAGULANT HEPARIN DERIVATIVE AND USE THEREOF IN TREATING INFLAMMATORY BOWEL DISEASE

摘要

The present invention provides a non-anticoagulant heparin derivative and a use thereof in treating an inflammatory bowel disease. The anti-factor Xa of the non-anticoagulant heparin derivative is less than or equal to 70 IU/mg, preferably less than or equal to 60 IU/mg, preferably less than or equal to 50 IU/mg, preferably less than or equal to 40 IU/mg, preferably less than or equal to 30 IU/mg, preferably less than or equal to 20 IU/mg, and preferably less than or equal to 10 IU/mg. The anti-factor IIa of the non-anticoagulant heparin derivative is less than or equal to 175 IU/mg, preferably less than or equal to 170 IU/mg, preferably less than or equal to 160 IU/mg, preferably less than or equal to 150 IU/mg, preferably less than or equal to 140 IU/mg, preferably less than or equal to 130 IU/mg, preferably less than or equal to 120 IU/mg, preferably less than or equal to 110 IU/mg, preferably less than or equal to 100 IU/mg, preferably less than or equal to 90 IU/mg, preferably less than or equal to 80 IU/mg, preferably less than or equal to 70 IU/mg, preferably less than or equal to 60 IU/mg, preferably less than or equal to 50 IU/mg, preferably less than or equal to 40 IU/mg, preferably less than or equal to 30 IU/mg, preferably less than or equal to 20 IU/mg, and preferably less than or equal to 10 IU/mg.