ALTERNATIVE ACTIVATION OF MACROPHAGES (M2 CELLS) THROUGH THE POLYAMINE-eIF5a-HYPUSINE AXIS

摘要

The present invention relates to a method for determining whether a compound has the capability of inhibiting elF5a activation, comprising (a) contacting a sample comprising cells being capable of differentiating into M2 macrophages with the compound under conditions that allow for the differentiation of cells into M2-type macrophages in the absence of the compound; and (b) quantifying in the sample the cells having a M2-phenotype, wherein a reduction of the number of cells having a M2-phenotype as compared to a control sample not contacted with the compound indicates that the compound has the capability of inhibiting elF5a activation.