RECOMBINANT PROTEIN AND FRAGMENTS THEREOF, METHOD FOR PRODUCING SAID RECOMBINANT PROTEIN, SYNTHETIC GENE AND USE OF THE SCULPTIN OR RECOMBINANT PROTEIN FOR PREPARING A MEDICAMENT OR PHARMACEUTICAL COMPOSITION FOR THE PROPHYLAXIS AND/OR TREATMENT OF THROMBOEMBOLIC DISEASES OR AS A DIRECT AND SPECIFIC INHIBITOR OF THROMBIN

摘要

The invention falls within the fields of biochemistry, molecular biology, genetics, pharmacy and medicinal chemistry, being related to biochemical and metabolic processes. More specifically, the present invention provides a novel class of proteins that inhibit thrombin, particularly direct inhibitors of thrombin modified from sculptin, identified in the transcriptomics analysis of the salivary glands of ticks, as well as fragments and recombinant protein thereof, which can be used as anticoagulant agents and for the prophylaxis and/or treatment of thromboembolic diseases.