METHOD TO PREDICT THE PROGRESSION OF ALZHEIMER'S DISEASE

摘要

The present invention relates to Alzheimer's and method to determine its progression and its severity. The inventors managed a study to phenotypically and functionally characterize human circulating PMNs in whole-blood at different disease stages in Alzheimer's patients. They also investigated associations between these indicators and rate of disease progression. They also showed (by luminex assays) that some proteins and particularly some cytokines could be used to predicting the severity of Alzheimer's disease. Thus, the present invention relates to methods for predicting the rapidity of progression of Alzheimer's or the severity of the disease in a patient by determining the activation state of neutrophils or the level of expression of different proteins (particularly cytokines).