PREPARING METHOD FOR AND USES OF 3,5-DISUBSTITUTED METHYLPYRAZOLO1,5-A PYRIMIDIN-7-PHENOLATE ANALOGUES AND DERIVATIVES

摘要

An object of the present invention is to provide: as an invention of an antibacterial and antifungal activity, 3-(2,4-difluorophenyl)-5-substituted-2-methylpyrazolo[1,5-a] pyrimidin-7-phenolate derivatives and analogues having the following general formula or prodrug, a preparation method and pharmacological activity test procedure therefor, and the pharmacological activity thereof; and a pharmaceutical chemical research and preparation method, and uses of the compounds as antibacterial and antifungal drugs. The definitions of R and M ⁺ in the general formula I are set forth in the description. The 3-(2,4-difluorophenyl)-5-substituted-2-methylpyrazolo[1,5-a] pyrimidin-7-phenolate derivatives and analogues of the formula I of the present application can be compatible with the other known antibacterial and antifungal drugs and drugs for treating bacterial infections with various complications, such as inflammation, viruses and immune system diseases.