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DECAPEPTIDE-12 MODULATION OF SIRTUIN GENE EXPRESSION IN EPIDERMAL KERATINOCYTE PROGENITORS
DECAPEPTIDE-12 MODULATION OF SIRTUIN GENE EXPRESSION IN EPIDERMAL KERATINOCYTE PROGENITORS
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机译:表皮基因角质形成祖细胞中沉默肽基因表达的DECAPEPTIDE-12调节
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摘要
Recent reports detail the pleiotropic roles sirtuins play in repressing premature aging, delaying cellular senescence, enhancing longevity, and ameliorating a wide range of aging disorders. Herein, we report our findings on the potent sirtuin activator, decapeptide-12, and compare its performance to the well documented oxyresveratrol. Treatment of human epidermal keratinocyte progenitors with 100µM decapeptide-12 increased transcription of SIRT1 by 141 ±11 percent relative to control cells, whereas levels of SIRT3, SIRT6, and SIRT7 were increased by 121± 13 percent, 147± 8 percent and 95.4 ±14 percent, respectively. Decapeptide-12 upregulated sirtuin transcription to similar levels as oxyresveratrol but with reduced cytotoxicity.
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