ANTIGEN-PRESENTING SIGNAL GROUP OF HEPATITIS B VIRUS ANTIGEN PEPTIDE COMBINED WITH LIVER CANCER CELL ANTIGEN INFORMATION AND APPLICATION THEREOF

摘要

An antigen-presenting signal group of a hepatitis B virus antigen peptide combined with liver cancer cell antigen information and an application thereof; the signal group consists of a hepatitis B virus (HBV) core antigen 18-27 peptide fragment, an HBV pre-S2 antigen 44-53 peptide fragment and human liver cancer cell line HepG2 lysate; the mass ratio of the HBV core antigen 18-27 peptide fragment, the HBV pre-S2 antigen 44-53 peptide fragment and the human hepatoma cell line HepG2 lysate is 0.5-1:0.5-1:1-2. Dendritic cells (DCs) which are induced by means of said signal group become a DC vaccine carrying antigen signals of a plurality of types of specific liver cancers which are correlated with the hepatitis B virus, which may activate the proliferation and function of tumor-specific T cells, thereby enhancing the effect thereof in preventing hepatitis B liver cancer.