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SYSTEMS-LEVEL ANALYSIS OF TCGA CANCERS REVEALS DISEASE TRNA FRAGMENTATION PATTERNS AND ASSOCIATIONS WITH MESSENGER RNAS AND REPEAT
SYSTEMS-LEVEL ANALYSIS OF TCGA CANCERS REVEALS DISEASE TRNA FRAGMENTATION PATTERNS AND ASSOCIATIONS WITH MESSENGER RNAS AND REPEAT
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机译:TCGA癌症揭示疾病TRNA片段模式及其与信使RNA和重复的关联的系统级分析
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摘要
Methods of treating a disease by leveraging positive and negative correlations between tRNA-derived fragments (tRF) and messenger RNA (mRNA) wherein said correlations can be used to establish a level of granularity that is specific to a disease of interest wherein said disease-specific positive and negative correlations can allow a level of therapeutic intervention that will be unprecedented because it will have been informed by three dimensions: at least one mRNA of interest; at least one tRF that are positively/negatively correlated with it; and, the identity of the disease in which one wishes to modulate the abundance of the at least one mRNA of interest.
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