DNA-RNA RNA NOVEL TETRAHEDRON NANOSTRUCTURE CONSISTING OF DNA-RNA HYBRID OR RNA

摘要

The present invention relates to a novel DNA-RNA hybrid tetrahedral or RNA tetrahedron structure capable of inhibiting the expression of a target gene or used for drug delivery, and more particularly, to a novel DNA-RNA hybrid tetrahedral structure or an RNA tetrahedral structure containing siRNA (small interfering RNA) or miRNA DNA-RNA hybrid tetrahedral structure or RNA tetrahedral structure.The present invention provides a functional RNA nanostructure into which siRNA or miRNA is introduced, so that the structure can be efficiently delivered to cells through self-propagation and can induce RNA interference mechanism to induce cell apoptosis of target cells. It is also possible to provide a controllable structure in which the drug is released to the outside by carrying the drug in the cavity. In addition, it is expected that the technology of the present invention can be commercialized as a new drug by preparing RNA nanostructures that cause suicide of target cells by using RNA interference action as the original technique.