- FUSION NANO LIPOSOME-NUCLEIC ACID FOR QUANTITATIVE DIAGNOSIS OF MULTI RIBONUCLEIC ACID MARKER METHOD FOR THEORETICAL STABILITY EVALUATION THEREOF USES THEREOF AND PREPARATION METHOD THEREOF

摘要

The present invention relates to a liposome-nucleic acid nano-fusion for the quantitative diagnosis of multiple ribonucleic acid markers, containing, in a liposome, a silica sphere having bound to the surface thereof a nucleic acid nano-structure having a first nucleic acid structure which is branched and has a cyclic end and a second nucleic acid structure which is branched and has a cyclic end, wherein the first nucleic acid structure and the second nucleic acid structure are bonded with the nucleic acid nano-structure; a theoretical stability evaluation method for the nano-fusion; an imaging system using the nano-fusion in disease diagnosis; and a production method for the nano-fusion. By using the liposome-nucleic acid nano-fusion according to the present invention, the difference in aspects of RNA expression among various cell lines may be quantitatively compared; and the difference among cells in a single cell line may be confirmed, thereby enabling real-time diagnosis of multiple intracellularly-expressed cancer-specific RNA markers acquired in an actual clinical setting, and on the basis thereof, information necessary for diagnosis and treatment may be easily acquired.