Compositions comprising tumor suppressor gene therapy and immune blockade for cancer therapy

摘要

The present invention provides methods and compositions for treating cancer in such individuals, comprising administering to the individual an effective amount of at least one immunostimulatory agent and p53 and / or MDA-7 (IL24) gene therapy. The invention also provides a method of increasing anti-tumor efficacy by administering an extracellular matrix-degrading protein. The present invention also provides a method for increasing anti-tumor efficacy by administering metronomic chemotherapy (5FU + CTX + GM-CSF in the case of the above-mentioned agents) with p53 and / or IL24 gene therapy.