IN-VIVO AND EX-VIVO AMPLIFICATION OF MYELOID-DERIVED IMMUNOMODULATORY CELLS OVEREXPRESSING IMMUNOREGULATORY MOLECULES

摘要

The present invention relates to in-vivo and ex-vivo amplification of myeloid-derived immunomodulatory cells overexpressing immunoregulatory molecules. More specifically, the present invention has confirmed that in a mouse in which inflammation is induced by administration of lipopolysaccharide (LPS) or in a mouse in which inflammation is induced by cecal ligation and puncture (CLP), the number of CD11b^+Gr1^(hi) cells is increased by administering sodium taurodeoxycholate (STDC) as a TGR5 agonist, wherein the CD11b^+Gr1^(hi) cells were CD244^+ surface phenotype myeloid-derived immunomodulatory cells with increased CD244 expression; and the myeloid-derived immunomodulatory cells exhibit therapeutic effects for sepsis. The method of the present invention may be used as a screening method for therapeutic agents for TGR5-related diseases or as an analysis method for efficacy of TGR5 agonists. Further, the myeloid-derived immunomodulatory cells of the present invention may be used as an effective component of a pharmaceutical composition for preventing or treating inflammatory diseases.;COPYRIGHT KIPO 2018