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CONTRAST AGENT FOR LIVER TISSUE-SPECIFIC IMAGING DIAGNOSIS COMPRISING MANGANESE SILICATE NANOPARTICLES

机译:含锰硅酸盐纳米颗粒的肝组织特定成像诊断对比剂

摘要

The present invention relates to an MRI contrast agent for liver tumor-specific imaging diagnosis comprising manganese silicate that emits manganese ions (Mn^(2+)) under acidic conditions, and to a method for characterizing liver tissues using the same. In a relatively short time, the pattern of T1-weighted imaging is different according to the tissue-specificity of normal liver tissues and disease tissues (particularly, liver tumors), such as vascularity, cell density, mitochondrial activity, hepatocellular affinity, and the like, and thus the disease-specific characteristic of liver tumors can be recognized at an appropriate time by analyzing the T1-weighted imaging. In particular, the present invention is expected to be very useful for diagnosing the type of liver tumor or determining a therapeutic effect, and moreover, is expected to be helpful in diagnosis according to tissue-specificity even in diseases generated in organs other than liver.;COPYRIGHT KIPO 2018
机译:本发明涉及一种用于肝脏肿瘤特异性成像诊断的MRI造影剂,其包括在酸性条件下发出锰离子(Mn ^(2+))的硅酸锰,并涉及使用该锰造影剂表征肝组织的方法。在相对较短的时间内,T1加权成像的模式会根据正常肝脏组织和疾病组织(尤其是肝脏肿瘤)的组织特异性(例如血管性,细胞密度,线粒体活性,肝细胞亲和力和因此,可以通过分析T1加权成像在适当的时间识别出肝脏肿瘤的疾病特异性特征。特别地,预期本发明对于诊断肝肿瘤的类型或确定治疗效果非常有用,此外,预期甚至在除肝脏以外的器官中产生的疾病中,根据组织特异性也有助于诊断。 ; COPYRIGHT KIPO 2018

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