Use of MMP-9 Facilitating a H3 N-terminal tail Proteolysis for proficient Osteoclastogenesis

摘要

The present invention is MMP-9-dependent H3NT decomposition and related relates to an osteoclast differentiation mechanisms, more specifically, MMP-9 is selectively cut in the histone H3 tail of the essential gene in the osteoclast differentiation mechanisms that promote osteoclast differentiation based, it relates to a method of screening the osteoclast related bone disease diagnostic composition too good screen and, using the same osteoclast related bone disease treatment too good screen material using H3NT protease function of MMP-9.;