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EXTRACELLULAR ALLOSTERIC INHIBITOR BINDING DOMAIN FROM A TYROSINE KINASE RECEPTOR
EXTRACELLULAR ALLOSTERIC INHIBITOR BINDING DOMAIN FROM A TYROSINE KINASE RECEPTOR
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机译:酪氨酸激酶受体的胞外异位抑制剂结合域
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摘要
The present invention relates to an extracellular binding domain for an allosteric inhibitor derived from a single membrane penetrating tyrosine kinase receptor. More specifically, the invention relates to extracellular domains derived from fibroblast growth factor receptor (FGFR). The invention further relates to the use of such domains for the identification of similar domains in the extracellular portion of other tyrosine kinase receptors, and to screening methods for identification of small compound allosteric inhibitors.
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