preparation method of pyridoisoindole derivatives

摘要

The present invention relates to a process for preparing a pyrido isoindole derivative which can be used as a main skeleton structure used in various fields such as pharmaceuticals, natural products, fluorescent substances and dyeing materials, and is characterized by using a carbene derivative capable of reacting with various nucleophiles To provide a process for the production of pyrido isoindole derivatives which is effective and more easily accessible only from the diazoacetate in the presence of a copper catalyst or only by heating without a copper catalyst. After the diazotization of the acetate derivative with basic catalyst and azide derivative, Cu (OTf)₂And the intramolecular cyclization reaction through the removal of nitrogen under a catalyst is carried out in a one-pot manner to provide an efficient production method of the pyridoindole derivative.