MHY498 Solid lipid nanoparticles composition for skin-whitening effect comprising MHY498 and preparation method thereof

摘要

The present invention relates to a solid lipid nanoparticle composition for skin whitening comprising MHY498 as an active ingredient and to a method for preparing the same. More particularly, the present invention relates to a method for preparing a solid lipid nanoparticle composition comprising MHY498 as solid lipid nanoparticles Sealing can form a sealing film when applied to the skin, and can act on the skin stratum corneum component to enhance the penetration of MHY498 into the skin. In addition, the solid lipid nanoparticles encapsulated with MHY498 are non-toxic and biocompatible and exhibit bi-phasic emission patterns, with initial rapid release facilitating MHY498 skin penetration by providing a sufficient concentration gradient , Sustained release maintains the local concentration, indicating the long-term anti-melanogenic effect of MHY498. Further, since the method of manufacturing solid lipid nanoparticles does not require high pressure and expensive equipment, it is possible to reduce manufacturing cost and increase productivity.