Composition for Prevention or Treatment of Inflammatory disease Comprising Extracellular Vesicles Derived from Lactic acid bacteria

摘要

The present invention relates to a composition for preventing, ameliorating, or treating an inflammatory disease comprising an extracellular endoplasmic reticulum-derived extracellular medium isolated from a culture broth of a lactic acid bacterium as an active ingredient, and a method for providing information for diagnosis of atopic dermatitis. The extracellular ER derived from lactic acid bacteria according to the present invention is significantly distributed in the urine and blood of patients with inflammatory diseases compared with normal persons and the inflammatory reaction of epithelial cells and inflammatory cells caused by exposure of extracellular ER from staphylococcus or Pseudomonas spp. As a result of in vitro and invivo experiments, it was confirmed that the composition containing the extracellular endoplasmic reticulum-derived extracellular matrix as an active ingredient can be used for the treatment of atopic dermatitis, chronic rhinitis, chronic sinusitis, asthma, Cosmetics, or health functional foods for the prevention, amelioration, or treatment of inflammatory diseases such as inflammation, inflammation, disease, or sepsis. In addition, it may be useful to diagnose atopic dermatitis by measuring the distribution of the extracellular endoplasmic reticulum (ER) derived from lactic acid bacteria in a urine or a blood sample.