oxalic acid derivatives, their use as u0445u0435u043cu043eu0441u0435u043du0441u0438u0431u0438u043bu0438u0437u0430u0442u043eu0440u043eu0432 in combination with u0446u0438u0442u043eu0441u0442u0430u0442u0438u043au0430u043cu0438 tumour therapy in the treatment of leukemia s and drug resistant leukemias.a way to obtain derivative of oxalic acid

摘要

FIELD: chemistry.SUBSTANCE: invention relates to oxalic acid derivatives of general formula RC(O)-C(O)R, where R=CHCH(-NH)C(O)ONa and Ph-CHCH(-NH)C(O)ONa, which can be used in the treatment of drug-resistant tumors.EFFECT: invention also relates to indicated oxalic acid derivatives as chemosensitizers in combination therapy of tumors with a drug resistance phenotype and means of increasing the effectiveness in the combined therapy of leukemia P388, as well as the way they are obtained.4 cl, 2 tbl, 4 ex