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COMPOSITIONS AND METHODS FOR PREVENTION OR TREATMENT OF DISEASES, STATE OR PROCESSES CHARACTERIZED BY ABERRANT PROLIFERATION OF FIBROBLASTS AND ACCUMULATION OF EXTRACELLULAR MATRIX
COMPOSITIONS AND METHODS FOR PREVENTION OR TREATMENT OF DISEASES, STATE OR PROCESSES CHARACTERIZED BY ABERRANT PROLIFERATION OF FIBROBLASTS AND ACCUMULATION OF EXTRACELLULAR MATRIX
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机译:预防或治疗成纤维细胞增殖和细胞外基质积聚所表征的疾病,状态或过程的组合物和方法
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摘要
The described invention provides compositions and methods for treating asthma, a disease, condition or pathologic process whose progression is characterized by one or more of aberrant fibroblast proliferation and extracellular matrix deposition producing constriction in an airway, airway remodeling, and airway obstruction in lung tissue. The method includes administering a pharmaceutical composition comprising a therapeutic amount of a polypeptide having the amino acid sequence YARAAARQARAKALARQLGVAA (SEQ ID NO: 1) or functional equivalent thereof, and a pharmaceutically acceptable carrier, wherein the therapeutic amount of the polypeptide is effective to reduce the constriction of small airway dimensions and airway obstruction, treat airway remodeling, or a combination thereof.
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机译:所描述的发明提供了用于治疗哮喘,疾病,病症或病理过程的组合物和方法,其进展的特征是异常的成纤维细胞增殖和细胞外基质沉积中的一种或多种在气道中产生收缩,气道重塑和肺组织中的气道阻塞。该方法包括给予药物组合物,该药物组合物包含治疗量的具有氨基酸序列YARAAARQARAKALARQLGVAA(SEQ ID NO:1)或其功能等同物的多肽,以及药学上可接受的载体,其中该治疗量的多肽可有效地降低缩小小气道尺寸和阻塞气道,治疗气道重塑,或其组合。
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