ARYLCYCLOALKYLAMINES DERIVATIVES NEUROPROTECTOR (VERSIONS), SUBSTANCES WITH COMBINED NEUROPROTECTOR, ANALGETIC AND ANTIDEPRESSIVE ACTION, PHARMACEUTICAL COMPOSITIONS BASED THEREON

摘要

FIELD: pharmacology.;SUBSTANCE: invention relates to new arylcycloalkylamines of the general formula ; . In the general formula (I), R¹, R² are H, linear or branched alkyl (C₁-C₄), linear or branched alkoxy (C₁-C₄), halogen; Y is -CH₂-O-CH₂-, - (CH₂)_n-, where n: 1-3; X is -CO-NH-(CH₂)₆-, -CO-(CH₂)_k-, -CH₂-NH-(CH₂)₆-, -CH(CH₃)-NH-(CH₂)₆-, -(CO)_p-(CHR⁵)_m, where p, m-: 0, 1, k: 2, 4-7, R⁵: H, linear alkyl C₁-C₅; R³, R⁴ are H, linear alkyl C₁-C₄, -CH₂-C≡CH, -(CH₂)₂-O-(CH₂)₂-NH₂, cyclopropyl, cyclopropylmethyl; 4-pyridinyl, an amino acid residue of a proteinogenic acyclic or aromatic α-amino acids, γ-aminobutyric acid, ε-aminocaproic acid, β-alanine; -CHR⁶-CH₂-OR⁷, where R⁶: H or a linear or branched alkyl C₁-C₄, benzyl, R⁷: H, linear alkyl C₁-C₄, or R³, R⁴ together with the nitrogen to which they are attached, form a pyrrolidine, 2-(hydroxymethyl) pyrolidine, 4-aminopyridinium ring; G is (C₁-C₄) carboxylic acid, methanesulfonic acid or a mineral acid or water. As an acyclic or aromatic α-amino acid residue, they contain a proteinogenic α-amino acid residue. As (C₁-C₄) carboxylic acid, they contain at least one compound from the group consisting of acetic, fumaric, succinic, tartaric, malic and maleic acids. As a mineral acid, they contain at least one compound from the group consisting of hydrochloric, phosphoric, sulfuric acids. The preferred compounds are arylcycloalkylamine derivatives of the general formula , wherein Y: -CH₂-O-CH₂-, -(CH₂)₂-. The invention also relates to a pharmaceutical composition which can be a combination of arylcycloalkylamine derivatives and at least one substance from the group comprising levodopa, palmitoyle ethanolamide, N-(2-aminoethyl) palmitamide hydrochloride, rasagiline, risperidone, toloxaton, quetiapine, gamma-aminobutyric acid, sodium valproate, amitriptyline, clomepramine, fluoxetine, paroxetine, sertraline, phenylephrine, dexamethasone, prednisolone. The composition may be in the form of a tablet, capsule, pellet, powder for preparation of a solution for enteral administration, a solution for parenteral administration, a powder for preparation of a solution for parenteral administration.;EFFECT: neuroprotective, analgesic and antidepressant action.;11 cl, 13 tbl, 96 ex