ANTIBODIES TO THE RELATED CANCER-EMBRYONIC ANTIGEN CELL ADHESION MOLECULE (CEACAM)

摘要

FIELD: biotechnology; medicine.;SUBSTANCE: present invention relates to biotechnology and medicine, namely to a monoclonal antibody that specifically binds to human CEACAM1. Present invention also discloses a polynucleotide encoding said antibody, a plasmid for its production, a pharmaceutical and diagnostic composition for the treatment of a malignancy characterized by the overexpression of CEACAM1, and for the detection of human CEACAM1, respectively. Method for preventing or treating a disease or disorder associated with the expression, activation or function of human CEACAM1, method of immunostimulation, method of inhibiting the interaction of human CEACAM1 with CEACAM1, as well as methods for diagnosing a malignant tumor expressing CEACAM1 are disclosed.;EFFECT: present invention allows to increase the specificity of antibodies against human CEACAM1.;16 cl, 20 dwg, 1 tbl, 13 ex